A review of the literature on the use of PER among patients with DS/SCN1A mutation was conducted by three researchers who independently and blindly searched the following electronic databases: PubMed/MEDLINE, Google Scholar, and Embase using the following terms: "Dravet syndrome", "SCN1A", "sodium channelopathies", and "Perampanel". This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.