ELANE, OLFM4, and 3 defensin genes (DEFA1, DEFA1B, and DEFA4) displayed the largest fold change differences in CD.I compared to samples from control patients, whereas in UC.I the genes with the largest fold change difference were CD177, OLFM4, GPR84, MCEMP1, and HP. The gene discussed is DEFA4; the disease is Cowden disease.