Research has demonstrated that the PTEN inhibitor BpV1 in combination with phosphoinositide phosphatase myotubularin related protein 14 (MTMR14) can attenuate the interaction between PTEN and LC3B, thereby reducing excessive autophagy and preventing cell death caused by its overactivation, which also exhibits neuroprotective effects in cases of ischemic stroke (33). Here, PTEN is linked to ischemic stroke.