Inhibition of PTEN activity aggravates cisplatin-induced AKI and renal tubular cell apoptosis by further activating caspase 3 and upregulating Bax expression levels, which leads to the blockade of p53 signaling pathway activation, ultimately resulting in inflammatory cell infiltration and production of proinflammatory molecules (41, 62). This evidence concerns the gene CASP3 and acute kidney injury.