In line with this hypothesis, immunofluorescent analysis of murine orthotopic PDAC tumours revealed an overall decrease in the expression of pSTAT3Tyr705 in both TAMs (F480+/pSTAT3+ cells) (Figures 4A, B) and CAFs (αSMA+/STAT3+ cells) (Figures 4D, E) upon IGF blockade. This evidence concerns the gene IGF1 and neoplasm.