TRIM21 and Schwartz-Jampel syndrome: In SjS animal models, the passive transfer of TRIM21-positive serum from immunized mice to non-immunized model mice resulted in dysfunction of the salivary and lacrimal glands, along with local deposition of anti-TRIM21 antibodies in the glands (106), suggesting that anti-TRIM21 antibodies may be directly involved in the pathogenic process of SjS.