Anti-TRIM21 were the second most common autoantibodies in this SSc.Anti-TRIM21 was strongly associated with ILD (OR=1.53 [1.11-2.12], P=0.0091) and overlap syndrome (OR=2.06 [1.01-4.19], P=0.0059). The gene discussed is TRIM21; the disease is overlapping connective tissue disease.