Anti-Ro/anti-La, anti-mitochondrial, and anti-p25/p23 antibodies were most frequently detected in the cohort of 55.4% of the patients with SSc.Anti-Ro60, anti-centromere, and anti-Topo I had a strong association with pulmonary fibrosis.Anti-TRIM21 was not described with SSc-ILD in the cohort of the study. The gene discussed is CALR; the disease is systemic sclerosis.