KMT2C and breast cancer: KMT2C is a gene with a high number of mutations found in breast cancer, some of which are associated with chromatin function, affecting transcriptional mechanisms identified in breast tumorigenesis and development (122) and, in addition, KMT2C mutations observed in circulating tumor DNA (ctDNA) from six-month postoperative samples may be indicative of breast cancer recurrence and prognosis (123).