KMT2C also regulates the proliferation and transformation of tumor stem cells, and Gervais found that KMT2C regulates the proliferation of intestinal stem cells, and that its absence leads to an increase in the level of EGFR proteins, which promotes the self-renewal of intestinal stem cells and the overgrowth of tumor-like stem cells (63). Here, KMT2C is linked to neoplasm.