Under the stringent significant threshold, genetically predicted HP antibody levels, including anti-HP IgG, CagA, GroEL, OMP, UREA, VacA, and catalase antibody, showed no association with the risk of PD using the IVW method [odds ratio (OR), 1.00–1.08; P = 0.089–0.999; Table 1]. The gene discussed is S100A8; the disease is Parkinson disease.