TERT and neoplasm: In this study, the TERT expression in tumour was monitored which is identified as tumour proliferation factor. Here, the lactate production from substrate in case of TERT+ tumour is significantly higher than TERT healthy tissue. Whereas, the use of a TERT inhibitor as a therapy surrogate revealed significant reduction in lactate production at early time-points prior to observable changes in tumour volume. Thus, revealed pyruvate substrate could be an early predictor for treatment response.