Circadian clock regulators, such as antidepressants, antipsychotics, and mood stabilizers, which can regulate the expression of Bmal1, Clock, and Per1, decrease the incidence of HPA axis dysregulation in patients with T2D, improving their blood glucose and glycosylated hemoglobin levels (Min et al., 2023). Here, CLOCK is linked to type 2 diabetes mellitus.