INS and type 2 diabetes mellitus: Additionally, the peak change in RSNA responses (Fig. 2E) decreased significantly following insulin microinjections in the T2DM rats (Pre: 55 ± 20%, 1 h: 58 ± 44%, 2 h: 35 ± 16% in control vs. Pre: 108 ± 40%, 1 h: 58 ± 44%, 2 h: 35 ± 16% in T2DM, P = 0.023 for ANOVA group × time interaction).