Likewise, no differences were observed in resting RSNA between T2DM and control rats in either i.c.v. insulin (for ANOVA group × time interaction: P = 0.290, time: P = 0.013, group: P = 0.733) or vehicle studies (for ANOVA group × time interaction: P = 0.233, time: P = 0.362, group: P = 0.286). Here, INS is linked to type 2 diabetes mellitus.