­suggested that the effect of LCZ696 to alleviate cyclophosphamide-induced renal fibrosis was obviously superior to that of valsartan, and the protective effect may owe to the ability to downregulate TGF-β/Smad2,3/PAI-1 and NF-κB signaling [44]. Here, TGFB1 is linked to renal fibrosis.