2003; Wilson et al. 2005; Parvani et al. 2011). In a recent study, Vitiello et al. (Vitiello et al. 2021) suggested that TGFβ signaling exert tumor-suppressive effects in luminal-B-HER2+ and p53-negative in breast cancers. Additionally, in humans TGFβ and FoxP3 have an active role in the VEGF signaling and in tumor angiogenic switch by promoting an increased intratumoral microvessel density, which contributes to mammary carcinogenesis and poor prognosis (Gupta et al. 2007; Kajal et al. 2021). This evidence concerns the gene TP53 and neoplasm.