2016; Juang et al. 2016; Xie et al. 2018). Furthermore, TGFβ seems to shape the tumor microenvironment and, when produced in excess by tumor cells, act in a paracrine manner on the peritumoral stroma, tumor neovessels and immune system resulting in increased cell–matrix interaction and angiogenic activity and suppressed immune surveillance which fosters tumor development (Gorsch et al. 1992; Bao et al. 2009; Lang et al. 2014; Ding et al. 2016; MaruYama et al. 2022). Here, TGFB1 is linked to neoplasm.