In PrCa, converse to what we have shown here, hypomethylation of WNT5A has been observed in primary prostate tumours27 most notably, in a study of 100 independent metastatic castration resistant PrCa tumours by Zhao et al., (2020), WNT5A was hypomethylated in these tumours and methylation was negatively correlated with WNT5A expression (p = 7.63 × 10−6),39 which supports our findings. Here, WNT5A is linked to pure red-cell aplasia.