Given its role as a tumour suppressor gene in multiple cancer types, methylation at the WNT5A promoter can also be paired with decreased expression,40, 41, 42 and increased DNA methylation is associated with multiple haematological malignancies,40, 41 oesophageal squamous cell carcinoma42 and ovarian cancer.43 The gene discussed is WNT5A; the disease is neoplasm.