To elucidate the significance of CD248+CAFs in NSCLC invasion and migration, the NSCLC cell lines A549 and NCI‐H460 were cocultured with CM derived from CAFs‐sh‐CON, CAFs‐sh‐CD248, or CAFs‐CD248OE, and then subjected to invasion and migration assays. The gene discussed is CD248; the disease is non-small cell lung carcinoma.