The expression of the deacetylase enzyme sirtuin 3 is downregulated in myocardial mitochondria after heart failure, leading to increased acetylation levels of complex I, aldehyde dehydrogenase 2, mitochondrial ribosomal protein L10, superoxide dismutase 2 (SOD2), long-chain acyl-CoA dehydrogenase, TFAM, PGC-1α, CYPD, leucine-rich protein 130 kD (LRP130), and LONP1. This evidence concerns the gene PPARGC1A and heart failure.