AKT1 and periodontitis: These include wound healing (e.g., Akt/eNOS signaling [156, 157]), myocardial IRI (e.g., CHK2/Beclin2 signaling [158]), OA in the temporomandibular joint (TMJ) (e.g., Akt/EKR/AMPK signaling [159]), corneal allograft rejection (e.g., Th1 signaling [160]), and periodontitis (e.g., RANKL/RANK/OPG signaling [161]).