Most dementia researchers are aware of some of the dementia-related neuropathologies, for example: Aβ and tau in amyloid plaques and neurofibrillary tangles of Alzheimer’s disease neuropathologic changes (ADNC) [34]; α-Synuclein in Lewy body diseases (LBDs) [35, 36]; and, TDP-43 proteinopathy in frontotemporal lobar degeneration (FTLD-TDP) [37] and in limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) [38]. The gene discussed is TARDBP; the disease is dementia.