Rac Family Small GTPase 1 (RAC1), a well-defined oncoprotein in NSCLC, drives its malignant progression by enhancing the proliferation, migration, and invasion abilities in tumor cells, which may be implicated in the RAC1-mediated activation of the MAPK/ERK and PI3K/AKT oncogenic signaling pathways [34, 46]. Here, AKT1 is linked to non-small cell lung carcinoma.