With an objective to explore the potential molecular mechanisms underlying the “two-sided” roles of FOSB in the malignant biological behaviors and cisplatin sensitivity in NSCLC cells expressing p53 in different statuses, three specific statuses of p53, namely the p53-Null, p53-WT, and p53-R248Q as highlighted above, were selected to be engaged in the following studies. Here, FOSB is linked to non-small cell lung carcinoma.