FOSB and non-small cell lung carcinoma: The analysis of the differentially expressed genes (DEGs) showed that FOSB overexpression induced significant up-regulation (FC > 1.5, P < 0.05) of the expression of a total of 177, 160, and 191 genes in NSCLC cells expressing p53-Null, p53-WT, and p53-R248Q, respectively (Fig. 4B).