Taken together, our current work confirmed the “two-sided” roles of FOSB in the malignant biological behaviors and cisplatin sensitivity in NSCLC cells with different genetic backgrounds of TP53. Since among all the mutation sites that were tested, FOSB overexpression exhibited the maximal facilitating effects on the malignant phenotypes (Fig. 3B-H) in NSCLC cells and a particular impact on their cisplatin sensitivity (Fig. 3I-K) in the presence of p53-R248Q, it was determined as the most meaningful and representative mutation site to be further investigated in follow-up studies. Here, TP53 is linked to non-small cell lung carcinoma.