The p53 protein, encoded by the TP53 gene, is activated via multiple pathways in response to a variety of exogenous or endogenous cellular stresses, and then blocks cellular malignant transformation, inhibits tumor progression, or promotes sensitization to radio-/chemo-therapy by mainly inducing cell cycle arrest, cell apoptosis, and cell senescence [18]. The gene discussed is TP53; the disease is neoplasm.