Secondly, in the genetic context of TP53-WT, the siRNA-mediated IGFBP5 knockdown substantially restored the proliferation (Fig. 6F), independent viability (Fig. 6G), migration (Fig. 6H), invasion (Fig. 6I), as well as the xenograft tumor growth in vivo (Fig. 6J) and its associated Ki-67 expression (Fig. 6K) that were all suppressed by FOSB overexpression in NSCLC cells. This evidence concerns the gene FOSB and neoplasm.