TP53 and neoplasm: For instance, the overexpression of Centromere Protein A (CENP-A) was shown to promote cell cycle arrest and cell senescence, and increase the radiosensitivity in a p53-dependent manner in tumor cells bearing wild-type TP53, while instead drive tumor invasion and metastasis, and decrease its radiosensitivity upon the absence of functional p53 expression [44].