RB1 and non-small cell lung carcinoma: Bearing this in mind, it should come as no surprise that the FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB), a classical AP-1 transcription factor, has been reported to play two-sided roles in the progression and prognosis of non-small cell lung cancer (NSCLC) [11, 13, 16, 17].