Secondly, in the genetic context of TP53-WT, the siRNA-mediated IGFBP5 knockdown substantially restored the proliferation (Fig. 6F), independent viability (Fig. 6G), migration (Fig. 6H), invasion (Fig. 6I), as well as the xenograft tumor growth in vivo (Fig. 6J) and its associated Ki-67 expression (Fig. 6K) that were all suppressed by FOSB overexpression in NSCLC cells. The gene discussed is TP53; the disease is non-small cell lung carcinoma.