Thus, the regulation by FOSB on the RAC1-ERK/AKT oncogenic signaling pathways via the specific transcriptional target PREX1 might be a critical molecular pathway through which it drives the malignant progression in NSCLC with the genetic background of TP53-Null (Figs. 5 and 6). This evidence concerns the gene FOSB and non-small cell lung carcinoma.