The CCK-8 cell proliferation assay showed that FOSB overexpression significantly promoted the proliferation in NSCLC cells expressing p53-Null, p53-R175H, p53-R248Q, and p53-R273L, while inhibited the proliferation in those expressing p53-WT (Fig. 3B). The gene discussed is TP53; the disease is non-small cell lung carcinoma.