Based on the well-validated tumor biological effects by FOSB overexpression in NSCLC cells across a range of different genetic backgrounds of TP53, three statuses of p53, namely the p53-Null, p53-WT, and p53-R248Q, were determined to be engaged in the follow-up mechanistic studies (Fig. 3). The gene discussed is FOSB; the disease is non-small cell lung carcinoma.