Additionally, the differential expression of FOSB between a group of human bronchial epithelial cell lines and NSCLC cell lines was further examined, and the results showed that FOSB mRNA (Fig. 1F) and protein (Fig. 1G-H) levels were consistently decreased in the NSCLC cell lines H1299, A549, H1650, LK2, PC-9, and H1975 compared to those in the bronchial epithelial cell lines 16HBE, HBE, and BEAS-2B. This evidence concerns the gene FOSB and non-small cell lung carcinoma.