The colony formation assay indicated that FOSB overexpression greatly enhanced the independent viability in NSCLC cells expressing p53-Null, p53-R175H, p53-R248Q, and p53-R273L, while substantially impaired the independent viability in those expressing p53-WT (Fig. 3C-D). The gene discussed is FOSB; the disease is non-small cell lung carcinoma.