In 2001, E12/E47 basic helix-loop-helix transcription factor (also called TCF3) was shown to evoke an EMT effect in MDCK kidney cells [61], and the ZEB family transcription factors, ZEB1 and ZEB2, were reported to induce an invasive phenotype in cancer cells [62], linking their function in regulating EMT. Here, ZEB2 is linked to cancer.