MAP2K3 and neoplasm: Moreover, AT9283 induced anti-tumor effects, recapitulating the MKK3 depletion effects, in all tested CRC cell lines, as: i) induced autophagy (Fig. 2A, B) and cell death (Fig. 2A, C, D); ii) induced G2/M phase cell cycle arrest (Fig. 2C, D); iii) reduced cell migration and invasion in vitro (Fig. 5); iv) reduced tumour growth in pre-clinical models (Fig. 6A).