These findings indicate that 2c nanoparticles can potentially modulate the effector immune cells with upregulation of pro-inflammatory cytokines, TNFα and IFNγ whereas downregulated anti-inflammatory cytokine, IL-10, along with Treg, Th17, pDC cell populations responsible for immunosuppressive CRC tumor milieu [74]. This evidence concerns the gene TNF and colorectal carcinoma.