Treating CRC mice with Apt-2cNP reduced carcinoma spreading and cancerous growth in the colons by 67.5% (p < 0.05) (Fig. 7B) as the percentage of ki67 positive cells in CRC was 80.45 ± 1.5 and that was found to reduce 26.44 ± 2.2 in the case of the Apt-2cNP treated mice. Here, MKI67 is linked to colorectal carcinoma.