NXPH4 and colorectal carcinoma: TCGA data analysis revealed elevated NXPH4 expression in tumors with advanced T and N classifications, as well as higher tumor grade in both CRC and HCC (Fig. S2A-B), highlighting NXPH4’s strong correlation with unfavorable prognosis in CRC and its association with OS and DSS in HCC (Fig. S2C–H).