TP53 (63%), ARID1A (23%), CDH1 (16%), APC (15%), LRP1B (13%), TGFBR2 (13%), FAT3 (11%), PIK3CA (9%), SMARCA4 (9%) and ACVR2A (8%) were the top 10 most frequently mutated SNV&INDEL genes, while CCNE1 (9%), FSR2 (8%) and MDM2 (8%) were the most frequent genes with CNVs in PC GC patients (Fig. 1A). The gene discussed is APC; the disease is pachyonychia congenita.