We classified 1969 BC patients from METABRIC dataset, containing clinical and genomic data from primary BC, into four different groups, based on the expression levels of SPAG5 and YAP signatures: SPAG5high/YAPhigh, SPAG5low/YAPlow, SPAG5high/YAPlow, SPAG5low/YAPhigh, (Heatmap Fig. 1A, B, Fig. S1A, B). This evidence concerns the gene SPAG5 and breast cancer.