Interestingly, SPAG5 overexpression was correlated with high levels of lymphocyte CD8+, macrophages, neutrophils, dendritic and B cells, positively associated with PD-1/PDL1, LAG3, GZMB and CTLA4 and SPAG5 antigens were suggested as valid immune stimulatory targets for anti-cancers therapy [40, 43, 44]. This evidence concerns the gene LAG3 and cancer.