Normalized high expression of SPAG5 and YAP were significantly associated with high levels of a TP53-dependent MYC-target gene signature (TP53-MYC target signature) in all BC (p = 5.1277 e-77) and in TNBC patients (p = 0.001) (Figs. 1F, S1E) [24]. The gene discussed is SPAG5; the disease is breast cancer.