Beyond similar frequencies of TP53 mutations 28.5% in SPAG5high/YAPlow and 33% in SPAG5low/YAPhigh groups, 41% of patients with YAPhigh and mut-p53 were associated with basal-like subtype (Fig. 1SA), while SPAG5 overexpression act as a self-sufficient supporter of tumor growth. The gene discussed is SPAG5; the disease is neoplasm.