All MYC proteins (MYC, from now on) control different cellular programs that regulate both cell-autonomous biology as well as the host’s immune system and tumor microenvironment (TME), primarily acting as an essential transcription factor that impacts diverse cellular processes, such as cell growth, cell cycle, differentiation, apoptosis, angiogenesis, metabolism, DNA repair, protein translation, mitochondrial biogenesis, immune response and stemness.16,115,116. This evidence concerns the gene MYC and neoplasm.