MYC and plasma cell myeloma: Besides being amplified, MYC is frequently involved in translocation events, such as within immunoglobulin loci in diffuse large B-cell lymphoma, Burkitt’s lymphoma and multiple myeloma, as well as T-cell receptor loci in T-cell acute lymphoblastic leukemia.23 In addition, multiple signaling pathways have been identified to modulate MYC gene expression, leading to MYC dysregulation in the absence of translocation or amplification.3