This study illustrates that CDK9 enhances MYC protein stability by directly phosphorylating MYC at Ser62.437 Recently, Macaya et al. elegantly demonstrated that MYC upregulation contributes to both MEKi and KRASi resistance in NSCLC, as MYC levels and its transcriptional activation were increased in resistant cells compared to sensitive ones. The gene discussed is MYC; the disease is non-small cell lung carcinoma.