Interestingly, this phenomenon depends on MYC levels, which modulate the epigenetic landscape and regulate the transcriptional activity of FOXA1, FOXA2 and ETS1.179 Apart from their cooperation in commonly mutated cancers, Pajovic and collegues also identified epigenetic activation of the RAS/MYC axis in tumors mutated in Histone H3 lysine 27 (H3K27M).180. This evidence concerns the gene MYC and cancer.