The RAL (RAS-Like) signaling pathway has also been implicated in regulating cell proliferation and survival as major effector of RAS62 interacting with several RAL-GEFs, such as the RAL guanine nucleotide dissociation stimulator (RALGDS), and activating the RAL GTPases RALA and RALB.81 Although RALA is pivotal for tumor growth and RALB holds importance in tumor metastasis and invasion, both isoforms can act redundantly in cancer development. This evidence concerns the gene RALGDS and neoplasm.