MYC and neoplasm: In the case of pancreatic tumors, MYC-driven IL-1β secretion increases the proliferation of endothelial cells.323 Immunosuppressive chemokine ligands CCL2 and CCL5 are also induced by MYC activation, recruiting mast cells to the tumor site.334 Moreover, MYC mediates the exclusion of antitumoral B cells by decreasing CXCL13 production.332 Thus, MYC deregulation significantly contributes to shaping the TME towards an immunosuppressive phenotype, eliciting clear immune evasion.