BRD4 inhibitors, such as JQ1, have shown promise in suppressing MYC and tumor growth, but their broad effects on other genes limit their clinical use due to toxicity.111 Alternative approaches aim to hinder MYC translation, such as antisense oligonucleotides or RNA interference using short/small hairpin (shRNA) or small interfering (siRNA) RNAs. The gene discussed is MYC; the disease is neoplasm.