MYC and cancer: Strong evidence supports aberrant MYC expression as a driver of both tumor initiation and maintenance and is associated with all the hallmark features of cancer.24–26 Besides being a renowned master regulator of cell proliferation and survival pathways, MYC is also implicated in many resistance mechanisms to targeted therapies.27 Consequently, the MYC pathway, along with MYC itself, has been regarded as a promising target for cancer therapy for several years.