MYC and cancer: Ample evidence demonstrates that MYC is involved in the initiation, maintenance and progression of several cancer types and is associated with all the hallmark features of cancer, including proliferation, self-renewal, cell survival, genomic instability, metabolism, invasiveness as well as angiogenesis and immune evasion.25,26 However, as previously mentioned, its activation alone generally is not sufficient to induce tumor progression, which requires other cooperative oncogenic lesions.26