Besides being amplified, MYC is frequently involved in translocation events, such as within immunoglobulin loci in diffuse large B-cell lymphoma, Burkitt’s lymphoma and multiple myeloma, as well as T-cell receptor loci in T-cell acute lymphoblastic leukemia.23 In addition, multiple signaling pathways have been identified to modulate MYC gene expression, leading to MYC dysregulation in the absence of translocation or amplification.3 The gene discussed is MYC; the disease is AL amyloidosis.