EPHB2 and Hepatic fibrosis: Considering that a better understanding of EphB2 PTMs may facilitate future researches on novel therapies for liver fibrosis and other EphB2-related disorders, in the present study we investigated the sulfenylation of EphB2 within HSCs during liver fibrosis and provided substantial evidence for the regulatory functions of sulfenylation on EphB2 kinase activity, protein stability, protein-protein interaction and downstream signaling.