TFEB and osteoporosis: Emerging discoveries demonstrated that TFEB overexpression promoted longevity and reduced the burden of diseases, holding great promise as a therapeutic strategy for multiple age-associated diseases.37,38 Regulation of TFEB has been shown to control the activities of osteoblasts and osteoclasts,39,40 the two main cells playing in the coupling of bone remodeling for homeostasis, implying its potential use in osteoporosis prevention.