However, gliomas rarely harbored multiple alterations within each pathway, a phenomenon commonly observed in cancer genomes (Figure 2B).23 Amongst RTKs, alterations in EGFR showed limited cooccurrence with PDGFRA (8.4%), MET (4.6%), and FGFR1-3 (2.7%, 2.4%, 2.4%, all P < .01). This evidence concerns the gene PDGFRA and central nervous system cancer.