CNP and myeloid sarcoma: In parallel with biochemical changes related to cuproenzyme function, the EAE spinal cord showed clear manifestation of axonal demyelination evident in G ratio changes (Fig. 6a and b; Additional file 1: Figs. S7b–f), white matter lesion volumes (Fig. 6c and d), and Luxol fast blue staining (Additional file 1: Fig. S7g) in addition to a decrease in levels of the myelin protein CNPase comparable to human MS (Additional file 1: Figs. S7h and i).