PROK2 and inflammatory bowel disease: As noted above, members of the Allobaculum genus can also produce ethanol.45,46 Furthermore, transcriptomic profiling following alcohol consumption in mice identified several differential expressed intestinal genes, one of which is prokineticin 2 (Prok2).36 Prokineticin 2 has pleiotropic effects and has been associated with IBD, neuronal survival and pain sensation.66–70 Surprisingly, the authors found that, among others, Allobaculum was negatively associated with Prok2, hinting at the possibility that Allobaculum spp.