Importantly, and contrary to previously published models of chronic ethanol consumption, we did not observe any evidence of liver damage in our model of chronic binge drinking, as assessed by histological analysis for the presence of steatosis, necrosis, portal or lobular inflammation; AST and ALT transaminase activity in the serum or increased serum AST/ALT ratio, which is associated with alcohol-related liver disease (Figure 1(h,i)). The gene discussed is GPT; the disease is steatosis.