To assess the joint effect of the two independent SNPs on HBV‐HCC OS, we combined the risk genotypes of METTL3 rs1263790 AA genotype and ADARB1 rs57884102 CT/TT genotypes into a genetic score as the number of combined risk genotypes, which classified all HCC patients into three groups (0, 1 and 2 risk genotypes). This evidence concerns the gene ADARB1 and hepatocellular carcinoma.