For example, STRING v11.5 identified a functional pathway between RANTES, TNF-α, IL-10, and IL-4 which builds on previous research that has shown that pro-inflammatory biomarkers TNF-α and RANTES/CCL-5 have higher concentrations with prolonged sedentary time [43–45], and have been linked to chronic diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, and cardiovascular disease [46–49]. Here, TNF is linked to rheumatoid arthritis.