While association results solely in individuals with low-risk APOL1 G1/G2 genotypes showed that our APOL3 variant was still strongly associated with increased risk for CKD, our stratified analyses identified that APOL3 p.Q58* contributes the most risk for renal disease in patients who carry 1 copy of an APOL1 G1 or G2 risk allele, suggesting a complex epistatic interaction with APOL1 G1/G2. Here, APOL1 is linked to chronic kidney disease.