APOL3 and kidney disorder: We found that the APOL3 variant was strongly associated with decreased minimum estimated glomerular filtration rate (eGFR; P = 2.17 × 10–7, n = 10,435) and increased maximum creatinine (P = 3.85 × 10–6, n = 10,435), consistent with increased risk for renal disease (Supplemental Table 5).