Similarly, the APOL1 p.N264K protective variant also did not meet our significance threshold but was found to be nominally associated with decreased risk of nephritis, nephrosis, and renal sclerosis, with an OR of 0.43 (95% CI = 0.23–0.81, P = 4.63 × 10–3), and decreased risk of ESRD, with an OR of 0.64 (95% CI = 0.41–0.99, P = 2.18 × 10–2). This evidence concerns the gene APOL1 and nephritis.