Further digital pathology analyses revealed a significantly increased number of ICI-sensitive TCF1+PD1+CD8+ T cells in close proximity (<10 μm) to PanCyto+ tumor cells in the mTME of patients with HGSOC receiving NACT as compared to pTME samples (irrespective of NACT) and mTME samples from NACT-naïve patients (Fig. 4F and G). This evidence concerns the gene PDCD1 and neoplasm.