PDCD1 and neoplasm: Conversely, ICI-insensitive TIM-3+PD1+CD8+ T cells were in close proximity (<10 μm) of PanCyto+ tumor cells predominanty in pTME samples and mTME biopsies from NACT-naïve patients with HGSOC (Fig. 4G; Supplementary Fig. S10A and S10B).