Also, SSEA-4-positive cancer stem cells exhibited activation of PI3K/Akt pathway [37] which has been previously shown to enhance the transcriptional activity of nuclear factor-kappa B (NF-κB) [63], a key regulator of tumor necrosis factor receptor CD95, a complement regulatory protein CD59 expression as well as multidrug resistance [63–65]. The gene discussed is NFKB1; the disease is cancer.