Such strata analysis has also been performed in the present meta-analysis and the results pointed to a potential weaker association between fish consumption and APOE ε4 allele, a genetic marker associated with disturbed omega-3 PUFA metabolism leading to lower plasma concentrations than in non-carriers [90, 91], in which significant associations with lower risk of dementia and cognitive impairment were found. The gene discussed is APOE; the disease is dementia.