NOS3 and neurodegenerative disease: Some of the mechanisms potentially playing a role against neurodegenerative diseases reported to be exerted by bioactive peptides from seafood include modulation of inflammatory pathways and pro-survival and neurotrophic gene expression, improvement of cell viability, inhibition of acetylcholinesterase and endothelial nitric oxide synthase, and reduction of intracellular antioxidant enzymes depletion [76].