The accuracy to detect any type of neoplasia did not improve on other thresholds ≤20 μg Hb/g feces, with the 20 μg/g threshold specifically identifying only 3/4 CRCs, 2/5 advanced adenomas, 0/4 advanced serrated lesions, and 0/57 non-advanced adenomas, corresponding to a 7% sensitivity and 69% NPV. The gene discussed is GSTM1; the disease is neoplasm.