MSH6 and colorectal carcinoma: For individuals at lower risk for neoplasia—such as those having MSH6 or PMS2 variants (1,11,41–43) and no other risk factors for CRC (e.g., personal history of colorectal neoplasia, smoking, and overweight) (6,44,45)—a negative FIT could potentially extend the 2-year surveillance interval with, for example, 6–12 months, or even further if subsequent FITs also yield negative results.