In subjects with T2DM and diabetic peripheral neuropathy (DPN), serum Nrg4 levels were low [69], and they were negatively correlated with markers of inflammation and oxidative stress like hs-CRP, 8-iso-prostaglandin F2α (8-iso-PGF2α), and vibration perception threshold (VPT) in the plasma [70,71]. The gene discussed is NRG4; the disease is type 2 diabetes mellitus.