These outcomes were further confirmed in a prospective cohort study conducted by Ding et al. [74] reported that low plasma levels of Nrg4 were positively correlated with TC, TG, LDL, serum creatinine, urinary albumin/creatinine ratio, blood urea nitrogen, and blood uric acid, but negatively correlated with eGFR and HDL in patients with T2DM and diabetic nephropathy. The gene discussed is NRG4; the disease is type 2 diabetes mellitus.