SMARCA5 and Infertility: For example, it's reported that females with oocyte-specific depletion of SMARCA5 are infertile and oocytes lacking SMARCA5 fail to undergo meiotic resumption, and their RNA sequencing analysis of growing oocytes from early secondary follicles, secondary follicle as well as fully grown oocytes from preovulatory follicles showed down-regulated expression of HSF5-regulated genes Msh4, Meiob and Sycp1 (66).