Additionally, SLFN11 expression is known to be regulated by the transcription factor FLI1, which we found not to be expressed in the ACC cell lines (CU-ACC1, CU-ACC2, and NCI-H295R), and the expression levels of SLFN11 in the ACC cell line and surgical samples correlated positively with the expression of FLI1 (Supplementary Fig. S4C). Here, FLI1 is linked to adrenal cortex carcinoma.