To confirm this, we first verified the expression of P65, p‐P65, HIF‐1α and GLUT‐1 in HCC cells when GJB2 was knockdown, and the results showed that P65 did not change, while p‐P65, HIF‐1α and GLUT‐1 protein decreased significantly (Figure5A,B). The gene discussed is RELA; the disease is hepatocellular carcinoma.