To confirm this, we first verified the expression of P65, p‐P65, HIF‐1α and GLUT‐1 in HCC cells when GJB2 was knockdown, and the results showed that P65 did not change, while p‐P65, HIF‐1α and GLUT‐1 protein decreased significantly (Figure5A,B). Here, GJB2 is linked to hepatocellular carcinoma.