In order to gain a high-level view of the sources of heterogeneity in NSCLC, we extracted from RNA-seq data quantitative information on the cellular composition of the TME via deconvolution with quanTIseq21 and EPIC,22 as well as on pathway and transcription factor (TF) activity using PROGENy23 and collecTRI,24 respectively (STAR methods). Here, TF is linked to non-small cell lung carcinoma.