CD8A and neoplasm: The striking improvement in the BLCA cohort, from 0.49 to 0.67 median AUROC and from 0.14 to 0.31 median AUPRC (baseline AUPRC = 0.14), is in line with the major findings described in the original study, where the lack of response was associated with TGFβ signaling in fibroblasts and exclusion of CD8+ T cells from the tumor core.63