Differences in feature weights were more evident in cancer types with less marked iHet conservation, like androgen and mitogen-activated protein kinase (MAPK) pathways, as well as HNF1A and CEBPA TFs in kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), and prostate adenocarcinoma (PRAD). The gene discussed is HNF1A; the disease is prostate adenocarcinoma.