CircVAPA/miR—212—3p/Sirt1 axis also regulates Nrf2 and NLRP3 expression upon LPS challenge. By tar-getting miR—212—3p, circVAPA over—expression negatively regulates the expression of Sirt1 and pyroptosis—related factors (Nrf2 and NLRP3), which alleviates the inflammatory damages in sepsissinduced ALI. This evidence concerns the gene SIRT1 and acute respiratory distress syndrome.