PICK1 has a protective effect on sepsis-induced ALI. PICK1 deficiency can inhibit the PI3K/Akt/mTOR pathway. The inhibition of Akt and mTOR pathway may affect the reformation of autolysosome disrupt the autophagic flux in PICK1−/− mice, and aggravate ALI. Here, AKT1 is linked to acute respiratory distress syndrome.