CircVAPA/miR—212—3p/Sirt1 axis also regulates Nrf2 and NLRP3 expression upon LPS challenge. By tar-getting miR—212—3p, circVAPA over—expression negatively regulates the expression of Sirt1 and pyroptosis—related factors (Nrf2 and NLRP3), which alleviates the inflammatory damages in sepsissinduced ALI. The gene discussed is NFE2L2; the disease is acute respiratory distress syndrome.