NPM1 and acute myeloid leukemia: The most commonly mutated genes related to AML initiation and progression include FMS-related receptor tyrosine kinase 3 (FLT3), DNA methyltransferase three alpha (DNMT3A), nucleophosmin 1 (NPM1), and tet methylcytosine dioxygenase 2 (TET2) (Villatoro et al., 2020).