Further studies have shown that, unlike AML cells that carry multi-hit mutated TP53, those that carry monoallelic TP53 mutations frequently harbor co-mutations in genes like tet methylcytosine dioxygenase 2 (TET2), splicing factor 3b subunit 1 (SF3B1), ASXL transcriptional regulator 1 (ASXL1), RUNX family transcription factor 1 (RUNX1), isocitrate dehydrogenase (NADP(+)) 2 (IDH2), serine and arginine rich splicing factor 2 (SRSF2) (Shah et al., 2023), Mitogen-activated protein kinase kinase kinase 7 (TAK1), BCL6 corepressor (BCOR), and Cbl proto-oncogene (CBL) (Daver et al., 2023a). The gene discussed is MAP3K7; the disease is acute myeloid leukemia.