Notably, in cancers such as UCS (Breast Cancer) and GBM (Colorectal Adenocarcinoma), a significant positive correlation exists between THSD7B expression and the rest of mast cells, suggesting that elevated expression of THSD7B may promote mast cell release of immune factors, antigen presentation, and other effects, thereby allowing the tumor to present under immune surveillance, which is conducive to tumor growth and metastasis. This evidence concerns the gene THSD7B and glioblastoma.