From a mechanistic point of view, the upstream signaling molecules that exercise regulates THSD7B and how THSD7B regulates pathways such as estrogen signaling pathway, antigen processing and presentation, IL-17 signaling pathway, ferroptosis pathway, MicroRNAs in cancer, and lipid- and atherosclerosis-associated pathways have not been explored in this paper. The gene discussed is THSD7B; the disease is atherosclerosis.