Thus, while ABCE1 is a potential downstream target of cMyc and may positively participate in Myc-driven cancer growth (50), it is co-opted by Nsp1 to inhibit cMyc translation and cancer growth, making cMyc overexpressing cancer cells with up-regulated ABCE1 protein level particularly vulnerable to the effect of Nsp1. Here, SH2D3A is linked to cancer.