SH2D3A and brain neoplasm: ABCE1 OE also partially rescued Notch-induced brain tumor phenotype, and Nsp1/ABCE1 co-expression, which synergistically down-regulated dMyc translation as in cMyc case in mammalian cells, resulted in a more complete inhibition of Notch-induced NB overgrowth (Figs. 5C and S5F, G).