On the other hand, ABCE1 RNAi did not significantly affect the growth inhibition of GBM cells by Nsp1 (Fig. S4A), suggesting that ABCE1 facilitates Nsp1 function but it is not the only player mediating Nsp1 action, consistent with Nsp1 employing multipronged strategies to manipulate host cell function (48, 49). This evidence concerns the gene SH2D3A and glioblastoma.