Notably, complement genes (C1QA, C1QB, C1QC), apoptotic genes (PDL1, PDL2, APOL1, APOL2, FAS), inflammatory caspases (CASP1, CASP5), TLR pathway genes (TLR1, TLR4, TLR5, TLR8), cytokines (IL6, IL10), and granzyme (GZMB) were among the genes upregulated during symptomatic malaria (Fig. 1A). The gene discussed is PDCD1LG2; the disease is malaria.