Ubiquitinated and hyperphosphorylated carboxyl (C)-terminal fragments of TDP-43 generate cellular inclusions in both neuronal and glial cells (Mackenzie and Rademakers, 2008), while the aggregation of toxic superoxide dismutase 1 (SOD1) has been linked to some variants of ALS (Abati et al., 2020). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.