Ex vivo, oligomeric intracellular inclusion (250–670 kDa) extracted from N2a neuroblastoma cell lines after treatment with transgenic AD mouse brain extracts were found to induce inclusion formation in naive APP-expressing cell lines, suggesting that Aβ oligomers are capable of inducing seeded nucleation in a cellular model (Olsson et al., 2018). Here, APP is linked to Alzheimer disease.