CD4 and coronary artery disorder: One of the characteristics of CHD is chronic inflammation, especially where atherosclerotic plaque accumulation contains immune cytokines in various states of activation and differentiation, including CD4+ helper T-cells, CD8+ killer T cells, macrophages, and natural killer cells (NK cells) that secrete inflammatory mediator (Fernandez et al., 2019; Depuydt et al., 2020).