Upregulated expression of THAP7-AS1 facilitates the nuclear entry of the CUL4B protein, inhibiting the transcription of miR-22-3p and miR-320a, subsequently activating the PI3K/AKT signaling pathway and exerting oncogenic properties in GC (Liu H. T. et al., 2022). The gene discussed is PIK3CD; the disease is gastric cancer.