Molecular targeted therapy has made substantial strides in cancer treatment, emphasizing the increasing importance of targeting lncRNAs or the PI3K/AKT signaling pathway for therapeutic intervention for gastrointestinal tumors (Gao et al., 2022; Mortazavi et al., 2022; Maharati and Moghbeli, 2023). Here, PIK3CA is linked to digestive system neoplasm.