Dysregulation of the PI3K pathway, stimulated by various factors such as epigenetic alterations and environmental influences, is observed in gastrointestinal tumors, contributing to uncontrolled cell proliferation, survival, cell cycle progression, resistance to apoptosis, and chemoresistance (Chang et al., 2003; Danielsen et al., 2015; Papadatos-Pastos et al., 2015; Liu R. et al., 2020). This evidence concerns the gene PIK3CB and digestive system neoplasm.