After uptake and entry into GC cells, LINC01559 promotes cell proliferation, migration, and stemness by upregulating phosphoglycerate kinase 1 (PGK1) through miR-1343-3p sponge activity and inducing phosphatase and tensin homolog (PTEN) promoter methylation, resulting in downregulation. The gene discussed is PTEN; the disease is gastric cancer.